# OnCo record paper-dynamic-nejm-2022 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-dynamic-nejm-2022/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-dynamic-nejm-2022" ;
  schema:name "DYNAMIC: a blood test safely halved chemotherapy use after surgery for stage II colon cancer"@en ;
  schema:description "Giving chemotherapy only to patients with tumour DNA in their blood after surgery cut chemotherapy use from 28% to 15% with no loss in recurrence-free survival at two years."@en ;
  schema:url <https://onco.cc/key-papers/paper-dynamic-nejm-2022/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2200075>, <https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=368271>, <https://pubmed.ncbi.nlm.nih.gov/35657320/>, <https://europepmc.org/article/MED/35657320> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2200075> ;
  schema:datePublished "2022"^^xsd:gYear ;
  schema:author "Tie J, Cohen JD, Lahouel K, et al." ;
  onco:related <https://onco.cc/ideas/idea-ctdna-guided-adjuvant-crc/>, <https://onco.cc/pairings/ctdna-mrd-to-adjuvant/>, <https://onco.cc/biomarkers/ctdna-mrd-positive/>, <https://onco.cc/key-papers/paper-tie-ctdna-minimal-residual-disease-stage-ii-colon-sci-transl-med-2016/>, <https://onco.cc/key-papers/paper-galaxy-signatera-nat-med-2023/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/colon-cancer/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/>, <https://onco.cc/fronts/chemotherapy/> ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/drugs/signatera/> ;
  onco:institutions <https://onco.cc/institutions/peter-mac/>, <https://onco.cc/institutions/johns-hopkins/>, <https://onco.cc/institutions/wehi/> ;
  onco:terms <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/neoadjuvant-adjuvant/>, <https://onco.cc/terms/tumour-informed-assay/> ;
  onco:trials <https://onco.cc/trials/dynamic/> ;
  onco:people <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/kenneth-kinzler/>, <https://onco.cc/people/jeanne-tie/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dormancy-mrd/>, <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:journals <https://onco.cc/journals/nejm/> .