# OnCo record paper-echelon-1-brentuximab-avd-nejm-2018 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-echelon-1-brentuximab-avd-nejm-2018/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-echelon-1-brentuximab-avd-nejm-2018" ;
  schema:name "ECHELON-1: brentuximab vedotin replacing bleomycin in first-line chemotherapy for advanced Hodgkin lymphoma"@en ;
  schema:description "Swapping bleomycin for the CD30 antibody-drug conjugate brentuximab vedotin modestly improved disease control in advanced Hodgkin lymphoma and, at six years, improved survival."@en ;
  schema:url <https://onco.cc/key-papers/paper-echelon-1-brentuximab-avd-nejm-2018/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1708984>, <https://doi.org/10.1056/NEJMoa2206125>, <https://clinicaltrials.gov/study/NCT01712490> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa1708984> ;
  schema:datePublished "2018"^^xsd:gYear ;
  schema:author "Connors JM, Jurczak W, Straus DJ, et al." ;
  onco:related <https://onco.cc/key-papers/paper-swog-s1826-nivolumab-avd-nejm-2024/> ;
  onco:cancers <https://onco.cc/cancers/hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:targets <https://onco.cc/targets/cd30/> ;
  onco:drugs <https://onco.cc/drugs/brentuximab-vedotin/>, <https://onco.cc/drugs/doxorubicin/> ;
  onco:companies <https://onco.cc/companies/pfizer/>, <https://onco.cc/companies/takeda/> ;
  onco:terms <https://onco.cc/terms/pfs/>, <https://onco.cc/terms/os/> ;
  onco:trials <https://onco.cc/trials/echelon-1/>, <https://onco.cc/trials/hd21/>, <https://onco.cc/trials/swog-s1826/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-survivorship/> ;
  onco:journals <https://onco.cc/journals/nejm/> .