# OnCo record paper-engelman-met-amplification-gefitinib-resistance-science-2007 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-engelman-met-amplification-gefitinib-resistance-science-2007/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-engelman-met-amplification-gefitinib-resistance-science-2007" ;
  schema:name "MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling"@en ;
  schema:description "Some lung cancers escape a targeted pill without changing the target at all: they simply make many extra copies of a second receptor that switches the same growth signal back on."@en ;
  schema:url <https://onco.cc/key-papers/paper-engelman-met-amplification-gefitinib-resistance-science-2007/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.1141478>, <https://pubmed.ncbi.nlm.nih.gov/17463250/> ;
  schema:sameAs <https://doi.org/10.1126/science.1141478> ;
  schema:datePublished "2007"^^xsd:gYear ;
  schema:author "Engelman JA, Zejnullahu K, Mitsudomi T, et al." ;
  onco:related <https://onco.cc/biomarkers/met-amplification-readout/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/met/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/gefitinib/>, <https://onco.cc/drugs/erlotinib/> ;
  onco:institutions <https://onco.cc/institutions/mgh/>, <https://onco.cc/institutions/dana-farber/> ;
  onco:pathways <https://onco.cc/pathways/rtk-activation/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/resistance-routes-map/> ;
  onco:terms <https://onco.cc/terms/met-amplification/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/gene-amplification/> ;
  onco:people <https://onco.cc/people/pasi-janne/> ;
  onco:journals <https://onco.cc/journals/science/> .