# OnCo record paper-feig-cxcl12-fap-cafs-t-cell-exclusion-pnas-2013 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-feig-cxcl12-fap-cafs-t-cell-exclusion-pnas-2013/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-feig-cxcl12-fap-cafs-t-cell-exclusion-pnas-2013" ;
  schema:name "Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer"@en ;
  schema:description "Mice with pancreatic cancer had tumour-specific T cells but did not respond to checkpoint drugs; the fibroblasts were coating the cancer cells with a chemical, CXCL12, that kept T cells away, and blocking it let the T cells in and made anti-PD-L1 work."@en ;
  schema:url <https://onco.cc/key-papers/paper-feig-cxcl12-fap-cafs-t-cell-exclusion-pnas-2013/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1073/pnas.1320318110>, <https://pubmed.ncbi.nlm.nih.gov/24277834/> ;
  schema:sameAs <https://doi.org/10.1073/pnas.1320318110> ;
  schema:datePublished "2013"^^xsd:gYear ;
  schema:author "Feig C, Jones JO, Kraman M, et al." ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:targets <https://onco.cc/targets/fap/>, <https://onco.cc/targets/cxcr4/>, <https://onco.cc/targets/pdl1/>, <https://onco.cc/targets/ctla4/> ;
  onco:institutions <https://onco.cc/institutions/cruk-cambridge-centre/> ;
  onco:pathways <https://onco.cc/pathways/immune-desert-exclusion/>, <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/pathways/pd1-checkpoint/> ;
  onco:terms <https://onco.cc/terms/immune-exclusion/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:people <https://onco.cc/people/david-tuveson/> ;
  onco:journals <https://onco.cc/journals/pnas/> .