# OnCo record paper-gainor-alk-resistance-mutations-cancer-discov-2016 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-gainor-alk-resistance-mutations-cancer-discov-2016/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-gainor-alk-resistance-mutations-cancer-discov-2016" ;
  schema:name "Molecular mechanisms of resistance to first- and second-generation ALK inhibitors in ALK-rearranged lung cancer"@en ;
  schema:description "Rebiopsying 103 patients as each generation of drug failed showed that each drug leaves its own signature of escape mutations, and that whether a mutation is present decides whether the next drug in the sequence will work."@en ;
  schema:url <https://onco.cc/key-papers/paper-gainor-alk-resistance-mutations-cancer-discov-2016/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-16-0596>, <https://pubmed.ncbi.nlm.nih.gov/27432227/> ;
  schema:sameAs <https://doi.org/10.1158/2159-8290.CD-16-0596> ;
  schema:datePublished "2016"^^xsd:gYear ;
  schema:author "Gainor JF, Dardaei L, Yoda S, et al." ;
  onco:related <https://onco.cc/biomarkers/alk-fusion/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/organoids/> ;
  onco:targets <https://onco.cc/targets/alk/> ;
  onco:drugs <https://onco.cc/drugs/crizotinib/>, <https://onco.cc/drugs/ceritinib/>, <https://onco.cc/drugs/alectinib/>, <https://onco.cc/drugs/brigatinib/>, <https://onco.cc/drugs/lorlatinib/> ;
  onco:institutions <https://onco.cc/institutions/mgh/> ;
  onco:pathways <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/rtk-activation/>, <https://onco.cc/pathways/clonal-evolution/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/cross-resistance/>, <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/biopsy/> ;
  onco:people <https://onco.cc/people/justin-gainor/> ;
  onco:journals <https://onco.cc/journals/cancer-discovery/> .
