# OnCo record paper-gamble-preinvasive-treg-axis-lung-cancer-interception-nature-2026 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-gamble-preinvasive-treg-axis-lung-cancer-interception-nature-2026/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-gamble-preinvasive-treg-axis-lung-cancer-interception-nature-2026" ;
  schema:name "A preinvasive regulatory T cell axis for lung cancer interception"@en ;
  schema:description "Before lung cancer becomes invasive, a family of immune-dampening cells (effector regulatory T cells) builds up in the precancerous airway lining and in the blood, and rising levels marked people whose early cancers grew fast. In mice, blocking the PI3K-delta signal these cells depend on reduced lung tumours."@en ;
  schema:url <https://onco.cc/key-papers/paper-gamble-preinvasive-treg-axis-lung-cancer-interception-nature-2026/> ;
  schema:dateModified "2026-11-03"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41586-026-11066-6>, <https://pubmed.ncbi.nlm.nih.gov/42844481/> ;
  onco:tag "landmark-watch", "interception", "regulatory-t-cells" ;
  schema:sameAs <https://doi.org/10.1038/s41586-026-11066-6> ;
  schema:datePublished "2026"^^xsd:gYear ;
  schema:author "Gamble S, Whiteman ZE, Peinador-Marín C, et al." ;
  onco:related <https://onco.cc/ideas/idea-field-interception/>, <https://onco.cc/roadmaps/cure-paths/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/low-dose-ct-screening/> ;
  onco:targets <https://onco.cc/targets/pik3cd/> ;
  onco:institutions <https://onco.cc/institutions/uclh/> ;
  onco:pathways <https://onco.cc/pathways/tumor-microenvironment/> ;
  onco:terms <https://onco.cc/terms/t-cell/>, <https://onco.cc/terms/tertiary-lymphoid-structures/>, <https://onco.cc/terms/dysplasia/>, <https://onco.cc/terms/bronchoscopy/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/> ;
  onco:journals <https://onco.cc/journals/nature/> .