# OnCo record paper-gay-sclc-subtypes-inflamed-cancer-cell-2021 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-gay-sclc-subtypes-inflamed-cancer-cell-2021/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-gay-sclc-subtypes-inflamed-cancer-cell-2021" ;
  schema:name "Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities"@en ;
  schema:description "Reanalysing gene activity in small-cell lung cancer tumours found that the fourth kind is not defined by a control protein at all but by inflammation, and it is the one kind that clearly gains from adding immunotherapy."@en ;
  schema:url <https://onco.cc/key-papers/paper-gay-sclc-subtypes-inflamed-cancer-cell-2021/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.ccell.2020.12.014>, <https://pubmed.ncbi.nlm.nih.gov/33482121/> ;
  schema:sameAs <https://doi.org/10.1016/j.ccell.2020.12.014> ;
  schema:datePublished "2021"^^xsd:gYear ;
  schema:author "Gay CM, Stewart CA, Park EM, et al." ;
  onco:cancers <https://onco.cc/cancers/sclc/> ;
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  onco:institutions <https://onco.cc/institutions/md-anderson/> ;
  onco:pathways <https://onco.cc/pathways/sclc-signalling/>, <https://onco.cc/pathways/lineage-plasticity-neuroendocrine/>, <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/cancer-immunity-cycle/>, <https://onco.cc/pathways/transcription-addiction/> ;
  onco:terms <https://onco.cc/terms/cold-vs-hot/>, <https://onco.cc/terms/resistance/> ;
  onco:people <https://onco.cc/people/john-heymach/> ;
  onco:journals <https://onco.cc/journals/cancer-cell/> .