# OnCo record paper-george-sclc-genomic-profiles-nature-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-george-sclc-genomic-profiles-nature-2015/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-george-sclc-genomic-profiles-nature-2015" ;
  schema:name "Comprehensive genomic profiles of small cell lung cancer"@en ;
  schema:description "Sequencing 110 small-cell lung cancers found that losing both copies of TP53 and RB1 is obligatory. That is a loss of two brakes, not a gain of a target, which is why the disease has been so hard to drug."@en ;
  schema:url <https://onco.cc/key-papers/paper-george-sclc-genomic-profiles-nature-2015/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature14664>, <https://pubmed.ncbi.nlm.nih.gov/26168399/> ;
  onco:tag "lung-evidence" ;
  schema:sameAs <https://doi.org/10.1038/nature14664> ;
  schema:datePublished "2015"^^xsd:gYear ;
  schema:author "George J, Lim JS, Jang SJ, et al." ;
  onco:related <https://onco.cc/key-papers/paper-rudin-sclc-molecular-subtypes-nat-rev-cancer-2019/>, <https://onco.cc/key-papers/paper-dll3-sclc-clin-cancer-res-2019/>, <https://onco.cc/key-papers/paper-ahn-dellphi-301-tarlatamab-sclc-nejm-2023/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/sclc/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/>, <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/terms/ngs/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/rb1/>, <https://onco.cc/targets/notch1/>, <https://onco.cc/targets/dll3/> ;
  onco:pathways <https://onco.cc/pathways/notch/>, <https://onco.cc/terms/cell-cycle/> ;
  onco:terms <https://onco.cc/terms/driver-mutation/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-rare-cancers/>, <https://onco.cc/bottlenecks/b-preclinical-models/> ;
  onco:journals <https://onco.cc/journals/nature/> .