# OnCo record paper-george-small-cell-lung-cancer-genomes-nature-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-george-small-cell-lung-cancer-genomes-nature-2015/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-george-small-cell-lung-cancer-genomes-nature-2015" ;
  schema:name "Comprehensive genomic profiles of small cell lung cancer"@en ;
  schema:description "Sequencing the whole genomes of 110 small-cell lung cancers showed that losing both the p53 and the retinoblastoma genes is not merely common in this cancer, it is obligatory, and that a quarter of tumours have broken a signalling system that would otherwise force them to stop behaving like nerve cells."@en ;
  schema:url <https://onco.cc/key-papers/paper-george-small-cell-lung-cancer-genomes-nature-2015/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature14664>, <https://pubmed.ncbi.nlm.nih.gov/26168399/>, <https://www.cbioportal.org/study/summary?id=sclc_ucologne_2015> ;
  schema:sameAs <https://doi.org/10.1038/nature14664> ;
  schema:datePublished "2015"^^xsd:gYear ;
  schema:author "George J, Lim JS, Jang SJ, et al." ;
  onco:cancers <https://onco.cc/cancers/sclc/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/rb1/>, <https://onco.cc/targets/notch1/>, <https://onco.cc/targets/kmt2d/>, <https://onco.cc/targets/crebbp/>, <https://onco.cc/targets/ep300/>, <https://onco.cc/targets/pten/>, <https://onco.cc/targets/mycl/>, <https://onco.cc/targets/myc-gene/> ;
  onco:pathways <https://onco.cc/pathways/sclc-signalling/>, <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/notch/>, <https://onco.cc/pathways/lineage-plasticity-neuroendocrine/>, <https://onco.cc/pathways/chromosomal-instability/> ;
  onco:terms <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/somatic-mutations-wxs-wgs/>, <https://onco.cc/terms/copy-number-variation-term/> ;
  onco:people <https://onco.cc/people/roman-thomas/> ;
  onco:journals <https://onco.cc/journals/nature/> .