# OnCo record paper-gerlinger-intratumour-heterogeneity-nejm-2012 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-gerlinger-intratumour-heterogeneity-nejm-2012/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-gerlinger-intratumour-heterogeneity-nejm-2012" ;
  schema:name "Gerlinger: a single biopsy misses most of the mutations in a kidney tumour"@en ;
  schema:description "Sequencing multiple regions of four kidney cancers and their metastases showed that around two-thirds of mutations were not shared across the whole tumour, that good- and poor-prognosis gene signatures coexisted in the same tumour, and that different regions had independently hit the same genes."@en ;
  schema:url <https://onco.cc/key-papers/paper-gerlinger-intratumour-heterogeneity-nejm-2012/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1113205> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa1113205> ;
  schema:datePublished "2012"^^xsd:gYear ;
  schema:author "Gerlinger M, Rowan AJ, Horswell S, et al." ;
  onco:related <https://onco.cc/key-papers/paper-tracerx-100-nejm-2017/>, <https://onco.cc/ideas/idea-bio1-ctdna-clone-report/> ;
  onco:cancers <https://onco.cc/cancers/rcc/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:institutions <https://onco.cc/institutions/cruk/>, <https://onco.cc/institutions/francis-crick/> ;
  onco:pathways <https://onco.cc/pathways/clonal-evolution/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/vaf/> ;
  onco:people <https://onco.cc/people/charles-swanton/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-biomarker-validation/> ;
  onco:journals <https://onco.cc/journals/nejm/> .
