# OnCo record paper-grasso-mutational-landscape-lethal-crpc-nature-2012 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-grasso-mutational-landscape-lethal-crpc-nature-2012/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-grasso-mutational-landscape-lethal-crpc-nature-2012" ;
  schema:name "The mutational landscape of lethal castration-resistant prostate cancer"@en ;
  schema:alternateName "Grasso 2012"@en, "lethal CRPC exome rapid autopsy"@en ;
  schema:description "Fifty men who died of prostate cancer had their tumours sequenced within hours of death. Even after years of treatment the cancers carried few mutations, and the recurring ones were in genes that control how DNA is packaged and read rather than in classic cancer genes."@en ;
  schema:url <https://onco.cc/key-papers/paper-grasso-mutational-landscape-lethal-crpc-nature-2012/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature11125>, <https://pubmed.ncbi.nlm.nih.gov/22722839/>, <https://www.cbioportal.org/study/summary?id=prad_mich> ;
  onco:tag "prostate-evidence" ;
  schema:sameAs <https://doi.org/10.1038/nature11125> ;
  schema:datePublished "2012"^^xsd:gYear ;
  schema:author "Grasso CS, Wu YM, Robinson DR, et al." ;
  onco:related <https://onco.cc/key-papers/paper-baca-punctuated-evolution-chromoplexy-cell-2013/>, <https://onco.cc/key-papers/paper-robinson-integrative-clinical-genomics-advanced-prostate-cell-2015/>, <https://onco.cc/roadmaps/prostate-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/>, <https://onco.cc/fronts/epigenetics/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/foxa1/>, <https://onco.cc/targets/erg/>, <https://onco.cc/targets/tmprss2/>, <https://onco.cc/targets/androgen-receptor/>, <https://onco.cc/targets/kmt2d/>, <https://onco.cc/targets/kmt2c/> ;
  onco:institutions <https://onco.cc/institutions/michigan-rogel/> ;
  onco:pathways <https://onco.cc/pathways/ar-signaling/>, <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/prostate-cancer-signalling/> ;
  onco:terms <https://onco.cc/terms/tmb/>, <https://onco.cc/terms/ngs/>, <https://onco.cc/terms/chromoplexy/>, <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/somatic-mutations-wxs-wgs/> ;
  onco:people <https://onco.cc/people/arul-chinnaiyan/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-immunotherapy-response/>, <https://onco.cc/bottlenecks/b-tumor-heterogeneity/> ;
  onco:journals <https://onco.cc/journals/nature/> .