# OnCo record paper-hallmarks-new-dimensions-cancer-discov-2022 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-hallmarks-new-dimensions-cancer-discov-2022/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-hallmarks-new-dimensions-cancer-discov-2022" ;
  schema:name "Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells"@en ;
  schema:description "The third hallmarks paper proposed two new hallmarks (unlocking phenotypic plasticity, senescent cells) and two new enabling characteristics (non-mutational epigenetic reprogramming, polymorphic microbiomes), bringing the framework to fourteen elements."@en ;
  schema:url <https://onco.cc/key-papers/paper-hallmarks-new-dimensions-cancer-discov-2022/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-21-1059> ;
  schema:sameAs <https://doi.org/10.1158/2159-8290.CD-21-1059> ;
  schema:datePublished "2022"^^xsd:gYear ;
  schema:author "Hanahan D" ;
  onco:related <https://onco.cc/key-papers/paper-hallmarks-of-cancer-cell-2000/>, <https://onco.cc/terms/unlocking-phenotypic-plasticity/>, <https://onco.cc/terms/nonmutational-epigenetic-reprogramming/>, <https://onco.cc/terms/polymorphic-microbiomes/>, <https://onco.cc/terms/senescent-cells/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/>, <https://onco.cc/fronts/epigenetics/> ;
  onco:pathways <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/senescence/>, <https://onco.cc/pathways/microbiome-tumour/>, <https://onco.cc/pathways/cancer-stem-cells-plasticity/> ;
  onco:terms <https://onco.cc/terms/hallmarks-of-cancer/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-knowledge-diffusion/> ;
  onco:journals <https://onco.cc/journals/cancer-discovery/> .