# OnCo record paper-halo-301-pegvorhyaluronidase-jco-2020 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-halo-301-pegvorhyaluronidase-jco-2020/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-halo-301-pegvorhyaluronidase-jco-2020" ;
  schema:name "Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma"@en ;
  schema:description "The 2020 trial of an enzyme meant to dissolve the dense matrix around pancreatic tumours so chemotherapy could reach them: more tumours shrank, but patients lived no longer, and the drug was abandoned."@en ;
  schema:url <https://onco.cc/key-papers/paper-halo-301-pegvorhyaluronidase-jco-2020/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.20.00590>, <https://pubmed.ncbi.nlm.nih.gov/32706635/>, <https://clinicaltrials.gov/study/NCT02715804>, <https://doi.org/10.2217/fon-2017-0338> ;
  onco:tag "pancreatic-evidence" ;
  schema:sameAs <https://doi.org/10.1200/JCO.20.00590> ;
  schema:datePublished "2020"^^xsd:gYear ;
  schema:author "Van Cutsem E, Tempero MA, Sigal D, et al." ;
  onco:related <https://onco.cc/key-papers/paper-ozdemir-caf-depletion-accelerates-pancreatic-cancer-cancer-cell-2014/>, <https://onco.cc/key-papers/paper-mpact-nab-paclitaxel-gemcitabine-nejm-2013/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/metastatic-pdac/> ;
  onco:drugs <https://onco.cc/drugs/gemcitabine-nab-paclitaxel/> ;
  onco:terms <https://onco.cc/terms/desmoplasia/>, <https://onco.cc/terms/desmoplastic-stroma-rich/> ;
  onco:people <https://onco.cc/people/eric-van-cutsem/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-negative-results/>, <https://onco.cc/bottlenecks/b-tme-immunosuppression/> ;
  onco:journals <https://onco.cc/journals/jco/> .