# OnCo record paper-heracles-lancet-oncol-2016 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-heracles-lancet-oncol-2016/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-heracles-lancet-oncol-2016" ;
  schema:name "HERACLES: trastuzumab and lapatinib in HER2-amplified, KRAS wild-type metastatic colorectal cancer"@en ;
  schema:description "This small Italian trial was the first to show that HER2-amplified colorectal cancer responds to dual HER2 blockade, establishing HER2 as a genuine drug target in a disease where it had been ignored."@en ;
  schema:url <https://onco.cc/key-papers/paper-heracles-lancet-oncol-2016/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S1470-2045(16)00150-9>, <https://pubmed.ncbi.nlm.nih.gov/27108243/> ;
  schema:sameAs <https://doi.org/10.1016/S1470-2045(16)00150-9> ;
  schema:datePublished "2016"^^xsd:gYear ;
  schema:author "Sartore-Bianchi A, Trusolino L, Martino C, et al." ;
  onco:cancers <https://onco.cc/cancers/her2-amplified-colorectal/> ;
  onco:drugs <https://onco.cc/drugs/lapatinib/>, <https://onco.cc/drugs/trastuzumab/> ;
  onco:trials <https://onco.cc/trials/heracles/> ;
  onco:journals <https://onco.cc/journals/lancet-oncology/> .