# OnCo record paper-heracles-trastuzumab-lapatinib-her2-colorectal-lancet-oncol-2016 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-heracles-trastuzumab-lapatinib-her2-colorectal-lancet-oncol-2016/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-heracles-trastuzumab-lapatinib-her2-colorectal-lancet-oncol-2016" ;
  schema:name "Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES)"@en ;
  schema:description "The first trial to treat bowel cancer as a HER2 disease. Screening 914 patients to find 48 with extra HER2, it produced lasting responses in nearly a third of those treated, after every standard drug had failed."@en ;
  schema:url <https://onco.cc/key-papers/paper-heracles-trastuzumab-lapatinib-her2-colorectal-lancet-oncol-2016/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S1470-2045(16)00150-9>, <https://pubmed.ncbi.nlm.nih.gov/27108243/> ;
  schema:sameAs <https://doi.org/10.1016/S1470-2045(16)00150-9> ;
  schema:datePublished "2016"^^xsd:gYear ;
  schema:author "Sartore-Bianchi A, Trusolino L, Martino C, et al." ;
  onco:related <https://onco.cc/biomarkers/her2-ish-amplified/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/kras/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/lapatinib/> ;
  onco:institutions <https://onco.cc/institutions/niguarda-cancer-center/>, <https://onco.cc/institutions/candiolo/> ;
  onco:pathways <https://onco.cc/pathways/rtk-activation/> ;
  onco:trials <https://onco.cc/trials/heracles/> ;
  onco:people <https://onco.cc/people/andrea-sartore-bianchi/>, <https://onco.cc/people/salvatore-siena/> ;
  onco:journals <https://onco.cc/journals/lancet-oncology/> .