# OnCo record paper-herman-mlh1-promoter-hypermethylation-colorectal-pnas-1998 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-herman-mlh1-promoter-hypermethylation-colorectal-pnas-1998/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-herman-mlh1-promoter-hypermethylation-colorectal-pnas-1998" ;
  schema:name "Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma"@en ;
  schema:description "Most bowel cancers with a broken DNA spell-checker have not mutated the gene at all: they have switched it off chemically. Removing the chemical tag in the laboratory turned the gene, and the repair system, back on."@en ;
  schema:url <https://onco.cc/key-papers/paper-herman-mlh1-promoter-hypermethylation-colorectal-pnas-1998/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1073/pnas.95.12.6870>, <https://pubmed.ncbi.nlm.nih.gov/9618505/> ;
  schema:sameAs <https://doi.org/10.1073/pnas.95.12.6870> ;
  schema:datePublished "1998"^^xsd:gYear ;
  schema:author "Herman JG, Umar A, Polyak K, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/methylation-profiling/> ;
  onco:targets <https://onco.cc/targets/mlh1/>, <https://onco.cc/targets/mmr/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:pathways <https://onco.cc/pathways/mismatch-repair-msi/>, <https://onco.cc/pathways/epigenetic-reprogramming/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/lynch-syndrome/> ;
  onco:people <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/kenneth-kinzler/>, <https://onco.cc/people/stephen-baylin/> ;
  onco:journals <https://onco.cc/journals/pnas/> .