# OnCo record paper-holderfield-ras-on-multi-selective-inhibitor-nature-2024 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-holderfield-ras-on-multi-selective-inhibitor-nature-2024/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-holderfield-ras-on-multi-selective-inhibitor-nature-2024" ;
  schema:name "Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy"@en ;
  schema:description "The 2024 Nature paper describing the chemistry behind daraxonrasib: a reversible drug that clamps the active form of every RAS protein, mutant or normal, and shrank tumours across RAS-driven models."@en ;
  schema:url <https://onco.cc/key-papers/paper-holderfield-ras-on-multi-selective-inhibitor-nature-2024/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41586-024-07205-6>, <https://pubmed.ncbi.nlm.nih.gov/38589574/> ;
  onco:tag "pancreatic-evidence" ;
  schema:sameAs <https://doi.org/10.1038/s41586-024-07205-6> ;
  schema:datePublished "2024"^^xsd:gYear ;
  schema:author "Holderfield M, Lee BJ, Jiang J, et al." ;
  onco:related <https://onco.cc/roadmaps/kras-roadmap/>, <https://onco.cc/key-papers/paper-daraxonrasib-pancreatic-n-engl-j-med-2026/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/kras-inhibitors/> ;
  onco:targets <https://onco.cc/targets/kras/> ;
  onco:drugs <https://onco.cc/drugs/daraxonrasib/> ;
  onco:companies <https://onco.cc/companies/revolution-medicines/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:trials <https://onco.cc/trials/rasolute-302/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:journals <https://onco.cc/journals/nature/> .