# OnCo record paper-huggins-hodges-castration-serum-phosphatases-prostate-1941 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-huggins-hodges-castration-serum-phosphatases-prostate-1941/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-huggins-hodges-castration-serum-phosphatases-prostate-1941" ;
  schema:name "Huggins and Hodges 1941: the effect of castration, of oestrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate"@en ;
  schema:alternateName "Studies on prostatic cancer. I."@en, "Huggins and Hodges 1941"@en, "Huggins 1941 castration prostate cancer"@en ;
  schema:description "In 1941 two Chicago surgeons showed that removing a man's testicles, or giving him oestrogen, made advanced prostate cancer shrink and his blood chemistry improve, and that giving testosterone made it worse. It was the first time any cancer in any organ had been made to regress by a drug or a hormone."@en ;
  schema:url <https://onco.cc/key-papers/paper-huggins-hodges-castration-serum-phosphatases-prostate-1941/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.3322/canjclin.22.4.232>, <https://pubmed.ncbi.nlm.nih.gov/4625049/>, <https://www.nobelprize.org/prizes/medicine/1966/huggins/facts/>, <https://europepmc.org/article/MED/26773095> ;
  onco:tag "prostate-evidence" ;
  schema:datePublished "1941"^^xsd:gYear ;
  schema:author "Huggins C, Hodges CV." ;
  onco:related <https://onco.cc/roadmaps/hormonal-therapy-roadmap/>, <https://onco.cc/roadmaps/prostate-roadmap/>, <https://onco.cc/key-papers/paper-visakorpi-androgen-receptor-amplification-nat-genet-1995/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mhspc/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:sections <https://onco.cc/fronts/hormonal/> ;
  onco:targets <https://onco.cc/targets/androgen-receptor/> ;
  onco:terms <https://onco.cc/terms/adt/>, <https://onco.cc/terms/castration-resistance/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:journals <https://onco.cc/journals/cancer-research/> .