# OnCo record paper-iacobuzio-donahue-dpc4-failure-pattern-autopsy-jco-2009 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-iacobuzio-donahue-dpc4-failure-pattern-autopsy-jco-2009/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-iacobuzio-donahue-dpc4-failure-pattern-autopsy-jco-2009" ;
  schema:name "DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer"@en ;
  schema:description "Autopsies of 76 people who died of pancreatic cancer showed two ways the disease kills: 70% died with cancer spread through the body and 30% with a locally destructive tumour, and whether the SMAD4 (DPC4) gene was intact predicted which."@en ;
  schema:url <https://onco.cc/key-papers/paper-iacobuzio-donahue-dpc4-failure-pattern-autopsy-jco-2009/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.2008.17.7188>, <https://pubmed.ncbi.nlm.nih.gov/19273710/> ;
  schema:sameAs <https://doi.org/10.1200/JCO.2008.17.7188> ;
  schema:datePublished "2009"^^xsd:gYear ;
  schema:author "Iacobuzio-Donahue CA, Fu B, Yachida S, et al." ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/metastatic-pdac/>, <https://onco.cc/cancers/locally-advanced-pdac/> ;
  onco:targets <https://onco.cc/targets/smad4/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/tp53/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:pathways <https://onco.cc/pathways/tgf-beta/>, <https://onco.cc/pathways/metastatic-cascade/> ;
  onco:terms <https://onco.cc/terms/ihc/> ;
  onco:journals <https://onco.cc/journals/jco/> .