# OnCo record paper-iwai-pdl1-tumour-escape-pnas-2002 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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a schema:ScholarlyArticle ;
onco:kind "paper" ;
schema:identifier "paper-iwai-pdl1-tumour-escape-pnas-2002" ;
schema:name "Iwai and Honjo: tumours use PD-L1 to escape T cells, and blocking it restores attack"@en ;
schema:description "A decade after Honjo's group cloned PD-1 (1992), this study showed that tumour cells expressing PD-L1 resist killing by cytotoxic T cells in mice, and that anti-PD-L1 antibody or PD-1 deficiency restores tumour rejection, the foundation of PD-1/PD-L1 therapy."@en ;
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schema:dateModified "2026-09-08"^^xsd:date ;
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schema:datePublished "2002"^^xsd:gYear ;
schema:author "Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N" ;
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