# OnCo record paper-jamal-hanjani-tracerx-evolution-nsclc-nejm-2017 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-jamal-hanjani-tracerx-evolution-nsclc-nejm-2017/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-jamal-hanjani-tracerx-evolution-nsclc-nejm-2017" ;
  schema:name "Tracking the evolution of non-small-cell lung cancer"@en ;
  schema:description "TRACERx sequenced several regions of 100 lung tumours instead of one. The driver mutations were usually everywhere in the tumour, but three quarters had later mutations present in only part of it, and the messier the tumour, the worse the outcome."@en ;
  schema:url <https://onco.cc/key-papers/paper-jamal-hanjani-tracerx-evolution-nsclc-nejm-2017/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1616288>, <https://pubmed.ncbi.nlm.nih.gov/28445112/>, <https://clinicaltrials.gov/study/NCT01888601> ;
  onco:tag "lung-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa1616288> ;
  schema:datePublished "2017"^^xsd:gYear ;
  schema:author "Jamal-Hanjani M, Wilson GA, McGranahan N, et al." ;
  onco:related <https://onco.cc/key-papers/paper-abbosh-phylogenetic-ctdna-lung-cancer-nature-2017/>, <https://onco.cc/key-papers/paper-hill-lung-adenocarcinoma-air-pollutants-nature-2023/>, <https://onco.cc/key-papers/paper-sequist-genotypic-histological-evolution-egfr-resistance-sci-transl-med-2011/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/resectable-nsclc/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/terms/ngs/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/met/>, <https://onco.cc/targets/braf/>, <https://onco.cc/targets/tp53/> ;
  onco:institutions <https://onco.cc/institutions/francis-crick/> ;
  onco:terms <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/terms/driver-mutation/> ;
  onco:people <https://onco.cc/people/charles-swanton/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-biomarker-validation/> ;
  onco:journals <https://onco.cc/journals/nejm/> .