# OnCo record paper-karapetis-kras-cetuximab-colorectal-nejm-2008 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-karapetis-kras-cetuximab-colorectal-nejm-2008/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-karapetis-kras-cetuximab-colorectal-nejm-2008" ;
  schema:name "K-ras mutations and benefit from cetuximab in advanced colorectal cancer"@en ;
  schema:description "The first randomised proof that a mutation can say a drug will not work: in a trial of cetuximab against supportive care alone, only patients whose tumours had a normal K-ras gene lived longer."@en ;
  schema:url <https://onco.cc/key-papers/paper-karapetis-kras-cetuximab-colorectal-nejm-2008/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa0804385>, <https://pubmed.ncbi.nlm.nih.gov/18946061/> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa0804385> ;
  schema:datePublished "2008"^^xsd:gYear ;
  schema:author "Karapetis CS, Khambata-Ford S, Jonker DJ, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/cetuximab/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/wild-type/>, <https://onco.cc/terms/driver-mutation/> ;
  onco:people <https://onco.cc/people/christos-karapetis/> ;
  onco:journals <https://onco.cc/journals/nejm/> .