# OnCo record paper-kopetz-beacon-encorafenib-braf-colorectal-nejm-2019 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-kopetz-beacon-encorafenib-braf-colorectal-nejm-2019/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-kopetz-beacon-encorafenib-braf-colorectal-nejm-2019" ;
  schema:name "Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer (BEACON CRC)"@en ;
  schema:description "BRAF V600E bowel cancer had a median survival of four to six months after first-line failure. Blocking BRAF and EGFR together took it to nine, and made the doublet a standard."@en ;
  schema:url <https://onco.cc/key-papers/paper-kopetz-beacon-encorafenib-braf-colorectal-nejm-2019/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1908075>, <https://pubmed.ncbi.nlm.nih.gov/31566309/> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa1908075> ;
  schema:datePublished "2019"^^xsd:gYear ;
  schema:author "Kopetz S, Grothey A, Yaeger R, et al." ;
  onco:related <https://onco.cc/key-papers/paper-cremolini-tribe-folfoxiri-bevacizumab-lancet-oncol-2015/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/braf-v600e-colorectal/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/braf/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/encorafenib/>, <https://onco.cc/drugs/binimetinib/>, <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/folfiri/>, <https://onco.cc/drugs/irinotecan/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:trials <https://onco.cc/trials/beacon-crc/>, <https://onco.cc/trials/breakwater/> ;
  onco:people <https://onco.cc/people/scott-kopetz/>, <https://onco.cc/people/eric-van-cutsem/>, <https://onco.cc/people/josep-tabernero/>, <https://onco.cc/people/yoshino-takayuki/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:journals <https://onco.cc/journals/nejm/> .