# OnCo record paper-ku-rb1-trp53-lineage-plasticity-science-2017 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-ku-rb1-trp53-lineage-plasticity-science-2017/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-ku-rb1-trp53-lineage-plasticity-science-2017" ;
  schema:name "Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis and antiandrogen resistance"@en ;
  schema:description "Deleting two tumour suppressor genes in mouse prostate cancer let the tumour change cell type, spread, and shrug off hormone treatment, and a drug that resets the chromatin reversed it."@en ;
  schema:url <https://onco.cc/key-papers/paper-ku-rb1-trp53-lineage-plasticity-science-2017/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.aah4199>, <https://pubmed.ncbi.nlm.nih.gov/28059767/>, <https://europepmc.org/article/MED/28059767> ;
  schema:sameAs <https://doi.org/10.1126/science.aah4199> ;
  schema:datePublished "2017"^^xsd:gYear ;
  schema:author "Ku SY, Rosario S, Wang Y, et al." ;
  onco:related <https://onco.cc/roadmaps/prostate-roadmap/>, <https://onco.cc/key-papers/paper-mu-sox2-lineage-plasticity-science-2017/>, <https://onco.cc/ideas/idea-prostate-plasticity-surveillance-before-it-is-neuroendocrine/>, <https://onco.cc/pathways/lineage-plasticity-neuroendocrine/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/>, <https://onco.cc/cancers/prostate-nepc/> ;
  onco:targets <https://onco.cc/targets/rb1/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/pten/>, <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/sox2/>, <https://onco.cc/targets/androgen-receptor/> ;
  onco:pathways <https://onco.cc/pathways/lineage-plasticity-neuroendocrine/>, <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/ar-signaling/> ;
  onco:terms <https://onco.cc/terms/histologic-transformation/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/castration-resistance/> ;
  onco:journals <https://onco.cc/journals/science/> .