# OnCo record paper-kwak-crizotinib-alk-nsclc-nejm-2010 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-kwak-crizotinib-alk-nsclc-nejm-2010/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-kwak-crizotinib-alk-nsclc-nejm-2010" ;
  schema:name "Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer"@en ;
  schema:description "1,500 tumours were screened to find 82 patients with an ALK fusion. Of those, 57 percent responded to crizotinib, a drug originally developed against a different target."@en ;
  schema:url <https://onco.cc/key-papers/paper-kwak-crizotinib-alk-nsclc-nejm-2010/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1006448>, <https://pubmed.ncbi.nlm.nih.gov/20979469/>, <https://clinicaltrials.gov/study/NCT00585195> ;
  onco:tag "lung-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa1006448> ;
  schema:datePublished "2010"^^xsd:gYear ;
  schema:author "Kwak EL, Bang YJ, Camidge DR, et al." ;
  onco:related <https://onco.cc/key-papers/paper-soda-eml4-alk-fusion-nature-2007/>, <https://onco.cc/key-papers/paper-alk-nsclc-n-engl-j-med-2013/>, <https://onco.cc/key-papers/paper-peters-alex-alectinib-crizotinib-nejm-2017/>, <https://onco.cc/key-papers/paper-shaw-crizotinib-ros1-nejm-2014/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/alk-positive-nsclc/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/terms/fish/>, <https://onco.cc/terms/ngs/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/alk/>, <https://onco.cc/targets/met/> ;
  onco:drugs <https://onco.cc/drugs/crizotinib/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:institutions <https://onco.cc/institutions/mgh/> ;
  onco:terms <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/oncogene-addiction/>, <https://onco.cc/terms/brain-metastases/> ;
  onco:people <https://onco.cc/people/alice-shaw/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-brain-delivery/>, <https://onco.cc/bottlenecks/b-trial-enrolment/> ;
  onco:journals <https://onco.cc/journals/nejm/> .