# OnCo record paper-le-mismatch-repair-deficiency-pd1-solid-tumours-science-2017 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-le-mismatch-repair-deficiency-pd1-solid-tumours-science-2017/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-le-mismatch-repair-deficiency-pd1-solid-tumours-science-2017" ;
  schema:name "Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade"@en ;
  schema:description "The follow-up that took the same test across 12 different cancers and found the same answer, producing the first drug approval in history based on a molecular feature rather than an organ."@en ;
  schema:url <https://onco.cc/key-papers/paper-le-mismatch-repair-deficiency-pd1-solid-tumours-science-2017/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.aan6733>, <https://pubmed.ncbi.nlm.nih.gov/28596308/>, <https://europepmc.org/article/MED/28596308> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1126/science.aan6733> ;
  schema:datePublished "2017"^^xsd:gYear ;
  schema:author "Le DT, Durham JN, Smith KN, et al." ;
  onco:related <https://onco.cc/key-papers/paper-le-pd1-blockade-mismatch-repair-deficiency-nejm-2015/>, <https://onco.cc/key-papers/paper-keynote-158-pembrolizumab-msi-high-noncolorectal-jco-2020/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/msi-high-colorectal/> ;
  onco:sections <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/targets/mmr/>, <https://onco.cc/terms/tumour-agnostic/>, <https://onco.cc/terms/neoantigen/> ;
  onco:people <https://onco.cc/people/dung-le/>, <https://onco.cc/people/luis-diaz/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-immunotherapy-response/>, <https://onco.cc/bottlenecks/b-rare-cancers/> ;
  onco:journals <https://onco.cc/journals/science/> .
