# OnCo record paper-le-mmr-deficiency-pd1-nejm-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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a schema:ScholarlyArticle ;
onco:kind "paper" ;
schema:identifier "paper-le-mmr-deficiency-pd1-nejm-2015" ;
schema:name "Le 2015: PD-1 blockade works in tumours with mismatch-repair deficiency, whatever the organ"@en ;
schema:description "Pembrolizumab shrank tumours in 40% of colorectal and 71% of other cancers with faulty DNA mismatch repair, but in none with intact repair, tying immunotherapy response to mutation burden."@en ;
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schema:dateModified "2026-09-08"^^xsd:date ;
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schema:datePublished "2015"^^xsd:gYear ;
schema:author "Le DT, Uram JN, Wang H, et al." ;
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