# OnCo record paper-le-mmr-deficiency-science-2017 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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a schema:ScholarlyArticle ;
onco:kind "paper" ;
schema:identifier "paper-le-mmr-deficiency-science-2017" ;
schema:name "Le 2017: mismatch-repair deficiency predicts response to PD-1 blockade across twelve tumour types, leading to the first tissue-agnostic drug approval"@en ;
schema:description "Across 86 patients with 12 different dMMR cancers, pembrolizumab produced responses in 53% and complete responses in 21%, prompting the first approval of a cancer drug based on a genetic marker rather than tumour site."@en ;
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schema:dateModified "2026-09-08"^^xsd:date ;
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schema:datePublished "2017"^^xsd:gYear ;
schema:author "Le DT, Durham JN, Smith KN, et al." ;
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