# OnCo record paper-le-pd1-blockade-mismatch-repair-deficiency-nejm-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-le-pd1-blockade-mismatch-repair-deficiency-nejm-2015/>
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  onco:kind "paper" ;
  schema:identifier "paper-le-pd1-blockade-mismatch-repair-deficiency-nejm-2015" ;
  schema:name "PD-1 blockade in tumors with mismatch-repair deficiency"@en ;
  schema:description "Forty-one patients settled a decade of argument: colorectal cancers with a broken DNA spell-checker responded to immunotherapy in 40 percent of cases, and those without responded in none."@en ;
  schema:url <https://onco.cc/key-papers/paper-le-pd1-blockade-mismatch-repair-deficiency-nejm-2015/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1500596>, <https://pubmed.ncbi.nlm.nih.gov/26028255/>, <https://europepmc.org/article/MED/26028255> ;
  onco:tag "colorectal-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa1500596> ;
  schema:datePublished "2015"^^xsd:gYear ;
  schema:author "Le DT, Uram JN, Wang H, et al." ;
  onco:related <https://onco.cc/key-papers/paper-le-mismatch-repair-deficiency-pd1-solid-tumours-science-2017/>, <https://onco.cc/key-papers/paper-andre-keynote-177-pembrolizumab-msi-high-nejm-2020/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/msi-high-colorectal/> ;
  onco:sections <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/> ;
  onco:companies <https://onco.cc/companies/merck/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/targets/mmr/>, <https://onco.cc/terms/tumour-agnostic/>, <https://onco.cc/terms/neoantigen/> ;
  onco:people <https://onco.cc/people/dung-le/>, <https://onco.cc/people/luis-diaz/>, <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/kenneth-kinzler/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-immunotherapy-response/> ;
  onco:journals <https://onco.cc/journals/nejm/> .