# OnCo record paper-leach-allison-ctla4-blockade-science-1996 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-leach-allison-ctla4-blockade-science-1996/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-leach-allison-ctla4-blockade-science-1996" ;
  schema:name "Leach, Krummel and Allison: releasing the CTLA-4 brake makes mice reject tumours"@en ;
  schema:description "Injecting mice with an antibody that blocks the T-cell inhibitory receptor CTLA-4 caused established colon carcinomas and fibrosarcomas to be rejected and protected against re-challenge, the experiment that founded checkpoint immunotherapy."@en ;
  schema:url <https://onco.cc/key-papers/paper-leach-allison-ctla4-blockade-science-1996/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.271.5256.1734> ;
  schema:sameAs <https://doi.org/10.1126/science.271.5256.1734> ;
  schema:datePublished "1996"^^xsd:gYear ;
  schema:author "Leach DR, Krummel MF, Allison JP" ;
  onco:related <https://onco.cc/key-papers/paper-iwai-pdl1-tumour-escape-pnas-2002/> ;
  onco:cancers <https://onco.cc/cancers/melanoma/> ;
  onco:sections <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/ctla4/> ;
  onco:drugs <https://onco.cc/drugs/ipilimumab/> ;
  onco:institutions <https://onco.cc/institutions/md-anderson/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/> ;
  onco:trials <https://onco.cc/trials/checkmate-067/> ;
  onco:people <https://onco.cc/people/james-allison/>, <https://onco.cc/people/padmanee-sharma/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-immunotherapy-response/>, <https://onco.cc/bottlenecks/b-translational-valley/> ;
  onco:journals <https://onco.cc/journals/science/> .