# OnCo record paper-lee-six-somatic-mutation-normal-colorectal-crypts-nature-2019 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-lee-six-somatic-mutation-normal-colorectal-crypts-nature-2019/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-lee-six-somatic-mutation-normal-colorectal-crypts-nature-2019" ;
  schema:name "The landscape of somatic mutation in normal colorectal epithelial cells"@en ;
  schema:description "Reading the whole genome of hundreds of individual healthy bowel glands from 42 people found that about one in a hundred already carries a cancer-driving mutation by middle age. Polyps and cancers are the rare survivors of a process happening everywhere in the bowel lining."@en ;
  schema:url <https://onco.cc/key-papers/paper-lee-six-somatic-mutation-normal-colorectal-crypts-nature-2019/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41586-019-1672-7>, <https://pubmed.ncbi.nlm.nih.gov/31645730/> ;
  schema:sameAs <https://doi.org/10.1038/s41586-019-1672-7> ;
  schema:datePublished "2019"^^xsd:gYear ;
  schema:author "Lee-Six H, Olafsson S, Ellis P, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/single-cell-spatial/> ;
  onco:targets <https://onco.cc/targets/apc/>, <https://onco.cc/targets/kras/> ;
  onco:pathways <https://onco.cc/pathways/field-cancerisation/>, <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/mutagenesis-signatures/> ;
  onco:terms <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/mutational-signature/>, <https://onco.cc/terms/tmb/> ;
  onco:journals <https://onco.cc/journals/nature/> .