# OnCo record paper-lengauer-genetic-instability-colorectal-nature-1997 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-lengauer-genetic-instability-colorectal-nature-1997/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-lengauer-genetic-instability-colorectal-nature-1997" ;
  schema:name "Genetic instability in colorectal cancers"@en ;
  schema:description "Colorectal cancers come in two unstable flavours: a few cannot spell-check their DNA, and most cannot divide their chromosomes evenly. This paper measured the second kind for the first time and showed it is a real, continuing defect rather than an accident."@en ;
  schema:url <https://onco.cc/key-papers/paper-lengauer-genetic-instability-colorectal-nature-1997/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/386623a0>, <https://pubmed.ncbi.nlm.nih.gov/9121588/> ;
  schema:sameAs <https://doi.org/10.1038/386623a0> ;
  schema:datePublished "1997"^^xsd:gYear ;
  schema:author "Lengauer C, Kinzler KW, Vogelstein B." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:pathways <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/mismatch-repair-msi/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/copy-number-variation-term/> ;
  onco:people <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/kenneth-kinzler/> ;
  onco:journals <https://onco.cc/journals/nature/> .