# OnCo record paper-ligtenberg-epcam-deletion-msh2-silencing-nat-genet-2009 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-ligtenberg-epcam-deletion-msh2-silencing-nat-genet-2009/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-ligtenberg-epcam-deletion-msh2-silencing-nat-genet-2009" ;
  schema:name "Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1"@en ;
  schema:description "Some families with inherited bowel cancer have no mutation in any repair gene. The fault is in the neighbouring gene: losing its end makes it run on into the repair gene and chemically silence it, but only in the tissues where the neighbour is switched on."@en ;
  schema:url <https://onco.cc/key-papers/paper-ligtenberg-epcam-deletion-msh2-silencing-nat-genet-2009/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/ng.283>, <https://pubmed.ncbi.nlm.nih.gov/19098912/> ;
  schema:sameAs <https://doi.org/10.1038/ng.283> ;
  schema:datePublished "2009"^^xsd:gYear ;
  schema:author "Ligtenberg MJ, Kuiper RP, Chan TL, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/germline-testing/> ;
  onco:targets <https://onco.cc/targets/msh2/>, <https://onco.cc/targets/epcam/>, <https://onco.cc/targets/mmr/> ;
  onco:institutions <https://onco.cc/institutions/radboudumc/> ;
  onco:pathways <https://onco.cc/pathways/mismatch-repair-msi/>, <https://onco.cc/pathways/epigenetic-reprogramming/> ;
  onco:terms <https://onco.cc/terms/lynch-syndrome/>, <https://onco.cc/terms/hereditary-cancer-syndromes/>, <https://onco.cc/terms/germline-vs-somatic/> ;
  onco:journals <https://onco.cc/journals/nature-genetics/> .