# OnCo record paper-lynch-frameshift-vaccine-ccr-2020 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-lynch-frameshift-vaccine-ccr-2020/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-lynch-frameshift-vaccine-ccr-2020" ;
  schema:name "First trial of a vaccine against the shared neoantigens of mismatch-repair-deficient cancers"@en ;
  schema:description "A vaccine of three frameshift peptides shared by almost all microsatellite-unstable tumours was safe and induced immune responses in every patient with MSI colorectal cancer, opening the path to cancer interception vaccines for Lynch syndrome."@en ;
  schema:url <https://onco.cc/key-papers/paper-lynch-frameshift-vaccine-ccr-2020/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/1078-0432.CCR-19-3517>, <https://clinicaltrials.gov/study/NCT05078866> ;
  schema:sameAs <https://doi.org/10.1158/1078-0432.CCR-19-3517> ;
  schema:datePublished "2020"^^xsd:gYear ;
  schema:author "Kloor M, Reuschenbach M, Pauligk C, et al." ;
  onco:related <https://onco.cc/ideas/idea-interception-vaccines/>, <https://onco.cc/ideas/idea-moon-lynch-vaccine-phase3/>, <https://onco.cc/ideas/idea-prev-lynch-frameshift-vaccine-rct/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/endometrial/> ;
  onco:sections <https://onco.cc/fronts/prevention/>, <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/interception-vaccination/>, <https://onco.cc/technologies/shared-antigen-vaccine/> ;
  onco:institutions <https://onco.cc/institutions/heidelberg-nct/>, <https://onco.cc/institutions/dkfz/> ;
  onco:terms <https://onco.cc/terms/lynch-syndrome/>, <https://onco.cc/terms/msi/>, <https://onco.cc/terms/neoantigen/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-hereditary-risk/>, <https://onco.cc/bottlenecks/b-prevention-adoption/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:journals <https://onco.cc/journals/clinical-cancer-research/> .