# OnCo record paper-markowitz-tgfbr2-inactivation-msi-colon-science-1995 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-markowitz-tgfbr2-inactivation-msi-colon-science-1995/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-markowitz-tgfbr2-inactivation-msi-colon-science-1995" ;
  schema:name "Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability"@en ;
  schema:description "When a cell loses its DNA spell-checker, short repeated stretches of DNA slip. This paper found that one of the genes destroyed that way is the brake that stops bowel cells growing, which is how a repair defect becomes a cancer."@en ;
  schema:url <https://onco.cc/key-papers/paper-markowitz-tgfbr2-inactivation-msi-colon-science-1995/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.7761852>, <https://pubmed.ncbi.nlm.nih.gov/7761852/> ;
  schema:sameAs <https://doi.org/10.1126/science.7761852> ;
  schema:datePublished "1995"^^xsd:gYear ;
  schema:author "Markowitz S, Wang J, Myeroff L, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:targets <https://onco.cc/targets/tgfbr2/>, <https://onco.cc/targets/mmr/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:pathways <https://onco.cc/pathways/tgf-beta/>, <https://onco.cc/pathways/mismatch-repair-msi/> ;
  onco:terms <https://onco.cc/terms/msi/> ;
  onco:people <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/kenneth-kinzler/> ;
  onco:journals <https://onco.cc/journals/science/> .