# OnCo record paper-mateo-genomics-lethal-prostate-diagnosis-castration-resistance-jci-2020 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-mateo-genomics-lethal-prostate-diagnosis-castration-resistance-jci-2020/>
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  onco:kind "paper" ;
  schema:identifier "paper-mateo-genomics-lethal-prostate-diagnosis-castration-resistance-jci-2020" ;
  schema:name "Genomics of lethal prostate cancer at diagnosis and castration resistance"@en ;
  schema:description "Sequencing the original diagnostic biopsies of men who later died of prostate cancer showed the dangerous changes were already there at the start, years before the disease became resistant."@en ;
  schema:url <https://onco.cc/key-papers/paper-mateo-genomics-lethal-prostate-diagnosis-castration-resistance-jci-2020/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1172/JCI132031>, <https://pubmed.ncbi.nlm.nih.gov/31874108/> ;
  schema:sameAs <https://doi.org/10.1172/JCI132031> ;
  schema:datePublished "2020"^^xsd:gYear ;
  schema:author "Mateo J, Seed G, Bertan C, et al." ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/pten/>, <https://onco.cc/targets/brca/>, <https://onco.cc/targets/cdk12/>, <https://onco.cc/targets/atm/>, <https://onco.cc/targets/rb1/>, <https://onco.cc/targets/androgen-receptor/> ;
  onco:pathways <https://onco.cc/pathways/homologous-recombination-repair/>, <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/ar-signaling/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/clonal-evolution/> ;
  onco:terms <https://onco.cc/terms/biopsy/>, <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/driver-mutation/> ;
  onco:journals <https://onco.cc/journals/jci/> .