# OnCo record paper-misale-kras-acquired-resistance-anti-egfr-colorectal-nature-2012 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-misale-kras-acquired-resistance-anti-egfr-colorectal-nature-2012/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-misale-kras-acquired-resistance-anti-egfr-colorectal-nature-2012" ;
  schema:name "Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer"@en ;
  schema:description "Bowel cancers that respond to cetuximab almost always stop responding within a year. This paper showed why: KRAS-mutant cells take over, and their DNA shows up in the blood months before a scan changes."@en ;
  schema:url <https://onco.cc/key-papers/paper-misale-kras-acquired-resistance-anti-egfr-colorectal-nature-2012/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature11156>, <https://pubmed.ncbi.nlm.nih.gov/22722830/> ;
  schema:sameAs <https://doi.org/10.1038/nature11156> ;
  schema:datePublished "2012"^^xsd:gYear ;
  schema:author "Misale S, Yaeger R, Hobor S, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/panitumumab/> ;
  onco:institutions <https://onco.cc/institutions/candiolo/>, <https://onco.cc/institutions/niguarda-cancer-center/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/resistance-routes-map/> ;
  onco:terms <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/cfdna/> ;
  onco:people <https://onco.cc/people/alberto-bardelli/>, <https://onco.cc/people/rona-yaeger/>, <https://onco.cc/people/andrea-sartore-bianchi/>, <https://onco.cc/people/salvatore-siena/> ;
  onco:journals <https://onco.cc/journals/nature/> .