# OnCo record paper-mntx-302-thomas-nejm-2008 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-mntx-302-thomas-nejm-2008/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-mntx-302-thomas-nejm-2008" ;
  schema:name "Methylnaltrexone for opioid-induced constipation in advanced illness (MNTX 302)"@en ;
  schema:description "In people with advanced illness whose strong painkillers had caused constipation that laxatives could not shift, a methylnaltrexone injection produced a bowel movement within four hours in about half, against about one in seven on placebo, without undoing pain relief."@en ;
  schema:url <https://onco.cc/key-papers/paper-mntx-302-thomas-nejm-2008/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa0707377>, <https://pubmed.ncbi.nlm.nih.gov/18509120/>, <https://clinicaltrials.gov/study/NCT00402038> ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa0707377> ;
  schema:datePublished "2008"^^xsd:gYear ;
  schema:author "Thomas J, Karver S, Cooney GA, et al." ;
  onco:sections <https://onco.cc/fronts/supportive-care/> ;
  onco:drugs <https://onco.cc/drugs/methylnaltrexone/> ;
  onco:companies <https://onco.cc/companies/bausch-health/> ;
  onco:trials <https://onco.cc/trials/mntx-302/> ;
  onco:journals <https://onco.cc/journals/nejm/> .