# OnCo record paper-notta-punctuated-evolution-pancreatic-nature-2016 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-notta-punctuated-evolution-pancreatic-nature-2016/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-notta-punctuated-evolution-pancreatic-nature-2016" ;
  schema:name "A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns"@en ;
  schema:description "Tracking chromosome damage in tumour-enriched genomes showed that pancreatic cancer often does not acquire its driver mutations one at a time: in two-thirds of tumours a catastrophic mitotic error knocks out several at once, so the disease can become invasive in a jump."@en ;
  schema:url <https://onco.cc/key-papers/paper-notta-punctuated-evolution-pancreatic-nature-2016/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature19823>, <https://pubmed.ncbi.nlm.nih.gov/27732578/> ;
  schema:sameAs <https://doi.org/10.1038/nature19823> ;
  schema:datePublished "2016"^^xsd:gYear ;
  schema:author "Notta F, Chan-Seng-Yue M, Lemire M, et al." ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/cdkn2a/>, <https://onco.cc/targets/smad4/> ;
  onco:institutions <https://onco.cc/institutions/oicr/>, <https://onco.cc/institutions/princess-margaret/> ;
  onco:pathways <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/clonal-evolution/> ;
  onco:terms <https://onco.cc/terms/whole-genome-doubling/> ;
  onco:journals <https://onco.cc/journals/nature/> .