# OnCo record paper-offin-rb1-tp53-transformation-risk-jto-2019 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-offin-rb1-tp53-transformation-risk-jto-2019/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-offin-rb1-tp53-transformation-risk-jto-2019" ;
  schema:name "Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes"@en ;
  schema:description "Lung cancers with mutations in all three of the same genes make up only a twentieth of the targetable group, but they are the ones that turn into a different cancer, and they stop responding to treatment three times sooner than the rest."@en ;
  schema:url <https://onco.cc/key-papers/paper-offin-rb1-tp53-transformation-risk-jto-2019/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.jtho.2019.06.002>, <https://pubmed.ncbi.nlm.nih.gov/31228622/> ;
  schema:sameAs <https://doi.org/10.1016/j.jtho.2019.06.002> ;
  schema:datePublished "2019"^^xsd:gYear ;
  schema:author "Offin M, Chan JM, Tenet M, et al." ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/sclc/> ;
  onco:technologies <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/rb1/>, <https://onco.cc/targets/tp53/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/> ;
  onco:pathways <https://onco.cc/pathways/lineage-plasticity-neuroendocrine/>, <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/mutagenesis-signatures/> ;
  onco:terms <https://onco.cc/terms/histologic-transformation/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/mutational-signature/> ;
  onco:people <https://onco.cc/people/charles-rudin/> ;
  onco:journals <https://onco.cc/journals/journal-of-thoracic-oncology/> .