# OnCo record paper-ostrem-kras-g12c-nature-2013 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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a schema:ScholarlyArticle ;
onco:kind "paper" ;
schema:identifier "paper-ostrem-kras-g12c-nature-2013" ;
schema:name "Ostrem and Shokat: the hidden pocket that made KRAS G12C druggable"@en ;
schema:description "Using disulfide-tethering screens, Shokat's laboratory found small molecules that bind covalently to the mutant cysteine of KRAS G12C in a previously unknown pocket beneath switch II, locking the oncoprotein in its inactive GDP-bound state."@en ;
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schema:dateModified "2026-09-08"^^xsd:date ;
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schema:datePublished "2013"^^xsd:gYear ;
schema:author "Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM" ;
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