# OnCo record paper-ozdemir-caf-depletion-accelerates-pancreatic-cancer-cancer-cell-2014 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-ozdemir-caf-depletion-accelerates-pancreatic-cancer-cancer-cell-2014/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-ozdemir-caf-depletion-accelerates-pancreatic-cancer-cancer-cell-2014" ;
  schema:name "Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival"@en ;
  schema:description "The 2014 mouse study showing that removing the scar-forming cells around pancreatic tumours made the cancers more aggressive and the mice die sooner, the warning that the stroma is not simply an obstacle to be cleared."@en ;
  schema:url <https://onco.cc/key-papers/paper-ozdemir-caf-depletion-accelerates-pancreatic-cancer-cancer-cell-2014/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.ccr.2014.04.005>, <https://pubmed.ncbi.nlm.nih.gov/24856586/> ;
  onco:tag "pancreatic-evidence" ;
  schema:sameAs <https://doi.org/10.1016/j.ccr.2014.04.005> ;
  schema:datePublished "2014"^^xsd:gYear ;
  schema:author "Özdemir BC, Pentcheva-Hoang T, Carstens JL, et al." ;
  onco:related <https://onco.cc/key-papers/paper-halo-301-pegvorhyaluronidase-jco-2020/>, <https://onco.cc/key-papers/paper-moffitt-virtual-microdissection-subtypes-nat-genet-2015/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:targets <https://onco.cc/targets/fap/> ;
  onco:drugs <https://onco.cc/drugs/gemcitabine/>, <https://onco.cc/drugs/ipilimumab/> ;
  onco:institutions <https://onco.cc/institutions/md-anderson/> ;
  onco:pathways <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/pathways/tumor-microenvironment/> ;
  onco:terms <https://onco.cc/terms/desmoplasia/>, <https://onco.cc/terms/desmoplastic-stroma-rich/>, <https://onco.cc/terms/cancer-associated-fibroblasts/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-negative-results/> ;
  onco:journals <https://onco.cc/journals/cancer-cell/> .