# OnCo record paper-palles-germline-pole-pold1-proofreading-nat-genet-2013 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-palles-germline-pole-pold1-proofreading-nat-genet-2013/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-palles-germline-pole-pold1-proofreading-nat-genet-2013" ;
  schema:name "Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas"@en ;
  schema:description "Some families with many bowel polyps and early cancers have an inherited fault in the part of the copying machinery that checks its own work. The tumours end up with enormous numbers of mutations but normal-looking repeat sequences."@en ;
  schema:url <https://onco.cc/key-papers/paper-palles-germline-pole-pold1-proofreading-nat-genet-2013/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/ng.2503>, <https://pubmed.ncbi.nlm.nih.gov/23263490/> ;
  schema:sameAs <https://doi.org/10.1038/ng.2503> ;
  schema:datePublished "2013"^^xsd:gYear ;
  schema:author "Palles C, Cazier JB, Howarth KM, et al." ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/germline-testing/>, <https://onco.cc/technologies/wes-wgs/> ;
  onco:targets <https://onco.cc/targets/pole/>, <https://onco.cc/targets/pold1/> ;
  onco:institutions <https://onco.cc/institutions/oxford-cancer/> ;
  onco:pathways <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/ddr/> ;
  onco:terms <https://onco.cc/terms/pole-ultramutation/>, <https://onco.cc/terms/hereditary-cancer-syndromes/>, <https://onco.cc/terms/germline-vs-somatic/>, <https://onco.cc/terms/tmb/> ;
  onco:journals <https://onco.cc/journals/nature-genetics/> .