# OnCo record paper-pardoll-immune-checkpoint-blockade-nrc-2012 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-pardoll-immune-checkpoint-blockade-nrc-2012/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-pardoll-immune-checkpoint-blockade-nrc-2012" ;
  schema:name "Pardoll 2012: the blockade of immune checkpoints in cancer immunotherapy"@en ;
  schema:description "The review that named and organised the field of checkpoint blockade: tumours switch off attacking T cells through brakes such as CTLA-4 and PD-1, and antibodies that release those brakes can produce lasting responses."@en ;
  schema:url <https://onco.cc/key-papers/paper-pardoll-immune-checkpoint-blockade-nrc-2012/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc3239> ;
  schema:sameAs <https://doi.org/10.1038/nrc3239> ;
  schema:datePublished "2012"^^xsd:gYear ;
  schema:author "Pardoll DM." ;
  onco:related <https://onco.cc/key-papers/paper-hodi-ipilimumab-melanoma-nejm-2010/>, <https://onco.cc/key-papers/paper-topalian-anti-pd1-nejm-2012/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/pdl1/>, <https://onco.cc/targets/lag3/>, <https://onco.cc/targets/tim3/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/> ;
  onco:terms <https://onco.cc/terms/immune-checkpoint/>, <https://onco.cc/terms/irae/> ;
  onco:people <https://onco.cc/people/drew-pardoll/> .