# OnCo record paper-pathfinder-avapritinib-advanced-systemic-mastocytosis-nat-med-2021 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-pathfinder-avapritinib-advanced-systemic-mastocytosis-nat-med-2021/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-pathfinder-avapritinib-advanced-systemic-mastocytosis-nat-med-2021" ;
  schema:name "PATHFINDER: efficacy and safety of avapritinib in advanced systemic mastocytosis (phase 2 interim analysis)"@en ;
  schema:description "The confirmatory trial of avapritinib in advanced systemic mastocytosis again showed responses in three quarters of patients, with the drug clearing marrow mast cells and normalising tryptase in many, and it became the standard first-line targeted therapy."@en ;
  schema:url <https://onco.cc/key-papers/paper-pathfinder-avapritinib-advanced-systemic-mastocytosis-nat-med-2021/> ;
  schema:dateModified "2026-09-18"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41591-021-01539-8>, <https://pubmed.ncbi.nlm.nih.gov/34873345/> ;
  schema:sameAs <https://doi.org/10.1038/s41591-021-01539-8> ;
  schema:datePublished "2021"^^xsd:gYear ;
  schema:author "Gotlib J, Reiter A, Radia DH, et al." ;
  onco:cancers <https://onco.cc/cancers/advanced-systemic-mastocytosis/> ;
  onco:drugs <https://onco.cc/drugs/avapritinib/> ;
  onco:journals <https://onco.cc/journals/nature-medicine/> .