# OnCo record paper-peters-alex-alectinib-crizotinib-nejm-2017 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-peters-alex-alectinib-crizotinib-nejm-2017/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-peters-alex-alectinib-crizotinib-nejm-2017" ;
  schema:name "Alectinib versus crizotinib in untreated ALK-positive non-small-cell lung cancer"@en ;
  schema:description "A newer ALK drug that gets into the brain beat the original one, and did it with fewer side effects. ALEX is why nobody starts an ALK-positive patient on crizotinib any more."@en ;
  schema:url <https://onco.cc/key-papers/paper-peters-alex-alectinib-crizotinib-nejm-2017/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1704795>, <https://pubmed.ncbi.nlm.nih.gov/28586279/>, <https://clinicaltrials.gov/study/NCT02075840> ;
  onco:tag "lung-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa1704795> ;
  schema:datePublished "2017"^^xsd:gYear ;
  schema:author "Peters S, Camidge DR, Shaw AT, et al." ;
  onco:related <https://onco.cc/key-papers/paper-kwak-crizotinib-alk-nsclc-nejm-2010/>, <https://onco.cc/key-papers/paper-shaw-crown-lorlatinib-crizotinib-nejm-2020/>, <https://onco.cc/key-papers/paper-wu-alina-adjuvant-alectinib-nejm-2024/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/alk-positive-nsclc/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/alk/> ;
  onco:drugs <https://onco.cc/drugs/alectinib/>, <https://onco.cc/drugs/crizotinib/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/> ;
  onco:terms <https://onco.cc/terms/brain-metastases/>, <https://onco.cc/terms/driver-mutation/> ;
  onco:trials <https://onco.cc/trials/alex/> ;
  onco:people <https://onco.cc/people/solange-peters/>, <https://onco.cc/people/alice-shaw/>, <https://onco.cc/people/tony-mok/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-brain-delivery/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:journals <https://onco.cc/journals/nejm/> .