# OnCo record paper-planchard-flaura2-osimertinib-chemotherapy-nejm-2023 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-planchard-flaura2-osimertinib-chemotherapy-nejm-2023/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-planchard-flaura2-osimertinib-chemotherapy-nejm-2023" ;
  schema:name "Osimertinib with or without chemotherapy in EGFR-mutated advanced NSCLC"@en ;
  schema:description "FLAURA2 added chemotherapy to the standard EGFR tablet in 557 patients and cut the risk of the cancer growing by 38 percent, at the cost of chemotherapy's side effects for everybody."@en ;
  schema:url <https://onco.cc/key-papers/paper-planchard-flaura2-osimertinib-chemotherapy-nejm-2023/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2306434>, <https://pubmed.ncbi.nlm.nih.gov/37937763/>, <https://clinicaltrials.gov/study/NCT04035486> ;
  onco:tag "lung-evidence" ;
  schema:sameAs <https://doi.org/10.1056/NEJMoa2306434> ;
  schema:datePublished "2023"^^xsd:gYear ;
  schema:author "Planchard D, Jänne PA, Cheng Y, et al." ;
  onco:related <https://onco.cc/key-papers/paper-flaura-nejm-2018/>, <https://onco.cc/key-papers/paper-cho-mariposa-amivantamab-lazertinib-nejm-2024/>, <https://onco.cc/key-papers/paper-osimertinib-nsclc-n-engl-j-med-2020/> ;
  onco:cancers <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/egfr-mutant-nsclc/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/> ;
  onco:targets <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/>, <https://onco.cc/drugs/pemetrexed/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/carboplatin/> ;
  onco:companies <https://onco.cc/companies/astrazeneca/> ;
  onco:terms <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/oncogene-addiction/> ;
  onco:trials <https://onco.cc/trials/flaura2/> ;
  onco:people <https://onco.cc/people/david-planchard/>, <https://onco.cc/people/pasi-janne/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> ;
  onco:journals <https://onco.cc/journals/nejm/> .