# OnCo record paper-prasad-surrogate-endpoints-jama-im-2015 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
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<https://onco.cc/key-papers/paper-prasad-surrogate-endpoints-jama-im-2015/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-prasad-surrogate-endpoints-jama-im-2015" ;
  schema:name "Prasad: most surrogate endpoints in cancer trials correlate poorly with survival"@en ;
  schema:description "A systematic review of 36 trial-level meta-analyses found that in over half the surrogate endpoint (response rate, progression-free survival) had a low correlation with overall survival, and only about a quarter showed a strong correlation."@en ;
  schema:url <https://onco.cc/key-papers/paper-prasad-surrogate-endpoints-jama-im-2015/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamainternmed.2015.2829>, <https://doi.org/10.1001/jamainternmed.2015.5868> ;
  schema:sameAs <https://doi.org/10.1001/jamainternmed.2015.2829> ;
  schema:datePublished "2015"^^xsd:gYear ;
  schema:author "Prasad V, Kim C, Burotto M, Vandross A" ;
  onco:related <https://onco.cc/ideas/idea-tr1-surrogate-validation-programme/>, <https://onco.cc/ideas/idea-tr1-power-for-meaningful-benefit/>, <https://onco.cc/ideas/idea-prev-mced-stage-endpoint-surrogate/>, <https://onco.cc/ideas/idea-tr1-win-ratio-net-benefit-endpoint/> ;
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  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-regulatory-fragmentation/>, <https://onco.cc/bottlenecks/b-drug-pricing/>, <https://onco.cc/bottlenecks/b-patient-voice/> ;
  onco:journals <https://onco.cc/journals/jama-internal-medicine/> .