# OnCo record paper-protac-concept-sakamoto-pnas-2001 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
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<https://onco.cc/key-papers/paper-protac-concept-sakamoto-pnas-2001/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-protac-concept-sakamoto-pnas-2001" ;
  schema:name "The first PROTAC: a chimeric molecule that tags a protein for destruction"@en ;
  schema:description "Crews and Deshaies built a two-headed molecule linking a ligand for the target protein MetAP-2 to a peptide recognised by an E3 ubiquitin ligase, and showed it induced ubiquitination and degradation of the target, founding targeted protein degradation."@en ;
  schema:url <https://onco.cc/key-papers/paper-protac-concept-sakamoto-pnas-2001/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1073/pnas.141230798>, <https://doi.org/10.1126/science.aab1433> ;
  schema:sameAs <https://doi.org/10.1073/pnas.141230798> ;
  schema:datePublished "2001"^^xsd:gYear ;
  schema:author "Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, Deshaies RJ" ;
  onco:related <https://onco.cc/technologies/molecular-glue-platforms/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/>, <https://onco.cc/fronts/targeted-therapy/> ;
  onco:technologies <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/degrader-antibody-conjugate/> ;
  onco:targets <https://onco.cc/targets/estrogen-receptor/>, <https://onco.cc/targets/androgen-receptor/> ;
  onco:drugs <https://onco.cc/drugs/vepdegestrant/> ;
  onco:trials <https://onco.cc/trials/veritac-2/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:journals <https://onco.cc/journals/pnas/> .