# OnCo record paper-quigley-brca2-reversion-cfdna-parp-resistance-cancer-discov-2017 (paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/key-papers/paper-quigley-brca2-reversion-cfdna-parp-resistance-cancer-discov-2017/>
  a schema:ScholarlyArticle ;
  onco:kind "paper" ;
  schema:identifier "paper-quigley-brca2-reversion-cfdna-parp-resistance-cancer-discov-2017" ;
  schema:name "Analysis of circulating cell-free DNA identifies multiclonal heterogeneity of BRCA2 reversion mutations associated with resistance to PARP inhibitors"@en ;
  schema:description "When PARP inhibitors stop working in prostate cancer, the tumour has repaired the broken gene, and a blood test shows it has done so in several different ways at once."@en ;
  schema:url <https://onco.cc/key-papers/paper-quigley-brca2-reversion-cfdna-parp-resistance-cancer-discov-2017/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-17-0146>, <https://pubmed.ncbi.nlm.nih.gov/28450426/> ;
  schema:sameAs <https://doi.org/10.1158/2159-8290.CD-17-0146> ;
  schema:datePublished "2017"^^xsd:gYear ;
  schema:author "Quigley D, Alumkal JJ, Wyatt AW, et al." ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/brca/>, <https://onco.cc/targets/parp/> ;
  onco:pathways <https://onco.cc/pathways/homologous-recombination-repair/>, <https://onco.cc/pathways/base-excision-repair-parp/>, <https://onco.cc/pathways/synthetic-lethality-map/>, <https://onco.cc/pathways/resistance-routes-map/> ;
  onco:terms <https://onco.cc/terms/brca-reversion-mutations/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/cfdna/>, <https://onco.cc/terms/hrd/> ;
  onco:journals <https://onco.cc/journals/cancer-discovery/> .